Intended Use:
Ozempic® (semaglutide) is a once-weekly injectable prescription medication used to improve blood sugar (glucose) control in adults with type 2 diabetes, alongside diet and exercise. It may also be prescribed off-label for weight management in individuals with obesity or overweight and associated comorbid conditions.

Contraindications:
Do not use Ozempic® if:

• You or a family member has a history of medullary thyroid carcinoma (MTC)
• You have Multiple Endocrine Neoplasia syndrome type 2 (MEN 2)
• You have a known allergy to semaglutide or any of the components in the formulation
  
  

Warnings & Serious Risks:

• Thyroid tumors, including cancer: In rodent studies, semaglutide caused thyroid C-cell tumors. While relevance to humans is uncertain, avoid use in individuals with a personal or family history of MTC.
• Pancreatitis: Discontinue and contact your healthcare provider if you experience persistent, severe abdominal pain.
• Gallbladder disease: Watch for symptoms such as abdominal pain, yellowing of skin or eyes, or clay-colored stools.
• Kidney problems: Dehydration from gastrointestinal side effects may worsen kidney function.
• Hypoglycemia: More likely when used with insulin or sulfonylureas.
• Diabetic retinopathy: May worsen in individuals with a history of this condition.
• Suicidal thoughts or mood changes: Monitor for new or worsening mental health symptoms.
  
  

Common Side Effects:

• Nausea
• Vomiting
• Diarrhea
• Constipation
• Abdominal pain
• Headache
• Fatigue
• Indigestion
• Injection site reactions

Symptoms typically lessen over time as your body adjusts to the medication.

Drug Interactions:

• Insulin and sulfonylureas: May increase risk of hypoglycemia.
• Oral medications: Delayed gastric emptying may alter absorption; monitor any changes in therapeutic effect, especially with narrow therapeutic index drugs.
• Oral contraceptives: Discuss with your provider whether backup contraception is needed when starting or adjusting dosage.
  
  

Pregnancy & Breastfeeding:

• Ozempic® should not be used during pregnancy. Discontinue at least 2 months before planning conception.
• It is unknown whether semaglutide passes into breast milk. Discuss risks and benefits with your provider before using while nursing.
  
  

Administration:
Inject subcutaneously once weekly in the abdomen, thigh, or upper arm. Administer on the same day each week, with or without food. Rotate injection sites with each dose.

Storage:
Refrigerate (36°F to 46°F / 2°C to 8°C). Do not freeze. If necessary, pens can be kept at room temperature (up to 86°F / 30°C) for up to 56 days.

Emergency Situations:
Seek emergency care if you experience signs of severe allergic reaction, persistent vomiting, severe abdominal pain, or low blood sugar. Call 911 or visit the nearest emergency facility.

Disclaimer:
This safety information is for educational purposes and does not replace medical advice from a licensed provider. Always consult your healthcare provider before starting, stopping, or changing medications. Report side effects to the FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.